𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthese, resolution Optique et Radiolyse d'Acides amines A haute Activite Specifique: L-Ornithine (3H-3,4,5,5). L-Arginine (3H-3,4,5,5). Acide dl-Glutamique (3H-3,4) ET Acide dl-Glutamique (3H-3,4,4)

✍ Scribed by D. Ego; J. P. Beaucourt; L. Pichat

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
383 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

Ethy 2 2-acetylamin0-2-carbethoq-4-cyano-3-butene oate : -3 was prepared by condensation o f trans-I-bromo-2-cymoethylene : -2 with acetamidornalonate. -3 was catalytically reduced h t h t r i t i u m followed by 3 hydrolysis giving r i s e t o (3,4,5,5-H ) DL ornithine 5_spec. act. 103 Ci/M.

L-ormithine -S was isolated by preparative revzrsed phase HPLC on a chiral phase. From 6 , -(i(, 4 , 5 , 5 -H j DL arginine spec. a c t i v i t y : 90 Ci/mM was prepared by panidation and the 1 (+) enatiomer isolated by preparative HPLC. ethyZ sodio 3 Selective catalytic t r i t i a t i o n of 3 i n presence of t r i s ftriphenylphosphine) Rh followed by hydrolysis gave [ 3 , 4 -H J D L -g z u t h c acid spec. activ i t y 60 Ci/mM. [ 3 , 4 , 4 -H ] DL-glutamic acid spec. a c t i v i t y 90 Ci/mM was also obtained by catalytic t r i t i a t i o n of compound 1J foZlmed by hydrolysis.

3H-NMR analyses

were carried out i n each ease. Observations on the s e l f radiolysis under various storage conditions are reported.

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