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Synthese eines neuen Thienospirans: 6,7-Dihydro-1′-methyl-spiro[benzo[b]thiophen-4(5H),2′-piperidin]

✍ Scribed by Dipl.-Ing. Dr. Hannes Fröhlich; Dipl.-Ing. Günter Gmeiner; Prof. Dr. Fritz Sauter

Book ID
105353781
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
524 KB
Volume
332
Category
Article
ISSN
1615-4150

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✦ Synopsis

Synthesis of a New Thienospiran: 6,7‐Dihylro‐1′‐methyl‐spiro[benzo[j]thioxhen‐4(5H),2′‐piperidine]

The title spiro compound 6 – a N‐methyl derivative of a new parent system ‐ has been synthesized from nitrile 8 via 4‐phenoxybutylation, followed by modified Schmidt degradation, ensuing O‐deprotection and final cyclization. The constitution of the target compound and of all intermediates is established by ^1^H‐n.m.r. and ^13^C‐n.m.r.‐spectroscopy and by microelementary analysis.

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