✦ LIBER ✦

Synthese eines neuen Derivats der Insulinsequenz B1–8 mit verbesserter Löslichkeit

✍ Scribed by H. R. Bosshard

Publisher: John Wiley and Sons
Year: 1971
Tongue: German
Weight: 628 KB
Volume: 54
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19710540403

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✦ Synopsis

Abstract

The synthesis of the protected octapeptide N‐t‐butoxycarbonyl‐phenylalanyl‐valylasparaginyl‐glutaminyl‐N^im^‐tritylhistidyl‐leucyl‐S‐benzhydrylcysteinyl‐glycine‐hydrazide L

, corresponding to the amino‐terminal sequence of the insulin B‐chain, is described. Up to the protected octapeptide all intermediates have greatly improved solubility properties in neutral organic solvents in comparison with other synthetic derivatives of the same sequence.

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MERRIFIELD-synthese der insulinsequenz B

MERRIFIELD-synthese der insulinsequenz B 1–8 mit verschiedenen thiolschutzgruppen,

✍ Hammerström, Von Knut ;Lunkenheimer, Winfried ;Zahn, Helmut 📂 Article 📅 1970 🏛 Wiley (John Wiley & Sons) ⚖ 537 KB

## Abstract Durch die MERRIFIELD‐Synthese des Oktapeptid‐Derivats Phe‐Val‐Asn‐Gln‐His(Bzl)‐Leu‐Cys(R)‐Gly wurden die S‐Schutzgruppen R gleich Benzyl (Bzl), __p__‐Methoxybenzyl (Mbzl), Diphenylmethyl (Dpm), Trityl (Trt), Tetrahydropyranyl (Thp), Benzylthiomethyl (Btm), äthylcarbamoyl (Ec), Benzyloxy