Synthese Aldosteron-ähnlicher Corticosteroide. Racemisches 11-Dehydroaldosteron (rac.-18-Oxo-11-dehydrocorticosteron) Über Steroide, 223. Mitteilung

✍ Scribed by J. Schmidlin

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: German
• Weight: 669 KB
• Volume: 54
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.19710540809

✦ Synopsis

Abstract

Racemic 11‐dehydroaldosterone (rac.‐18‐oxo‐11‐dehydrocorticosterone) is prepared starting from the 3, 3; 20, 20‐bisethylene acetal of the racemic 3, 20‐dioxo‐11β, 21‐dihydroxy‐Δ‐pregnene‐18‐oic acid‐(18 → 11β)‐lactone, an intermediate obtained previously in the first total synthesis of aldosterone. A cyclic 18(21)‐hemiacetal structure is deduced for the new corticosteroid from spectroscopic and chemical evidence.