Synthese 2-Heteroaryl-substituierter 3,3,3-Trifluoralanin- und 3,3,3-Trifluormilchsäure-Derivate

✍ Scribed by Sewald, Norbert ;Burger, Klaus

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 678 KB
• Volume: 1992
• Category: Article
• ISSN: 0947-3440
• DOI: 10.1002/jlac.1992199201156

✦ Synopsis

Synthesis of 2‐Heteroaryl‐Substituted 3,3,3‐Trifluoroalanine and 3,3,3‐Trifluorolactic Acid Derivatives

Trifluoromethyl‐substituted alkynyl α‐amino acid as well as alkynyl α‐hydroxy acid esters and 1,3‐dipoles (nitrile oxides, diazoalkanes, phenyl azide) react regioselectively to give α‐trifluoromethyl‐substituted heterocyclic α‐amino and α‐hydroxy acid derivatives, respectively.