Synergy between T cell receptor β gene polymorphism and HLA–DR4 in susceptibility to rheumatoid arthritis
✍ Scribed by Dr. Hua Mu; Patrick Charmley; Mary-Claire King; Lindsey A. Criswell
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 680 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed
Objective. To analyze the CD4؉ ؉ ؉ T cell responses to the human cartilage antigen glycoprotein-39 (HCgp-39) in the context of rheumatoid arthritis (RA)-associated (DR␣1\*0401) and nonassociated (DR␣1\*0402) HLA class II molecules. Methods. Large numbers of HCgp-39-specific T cell hybridomas were