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Synergistic Proliferative Action of Insulin-like Growth Factor I and 17 β-Estradiol in MCF-7S Breast Tumor Cells

✍ Scribed by Irene H.L. Hamelers; Richard F.M.A. van Schaik; Hetty A.A.M. van Teeffelen; John S. Sussenbach; Paul H. Steenbergh


Book ID
115604190
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
225 KB
Volume
273
Category
Article
ISSN
0014-4827

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## Abstract Human breast cancer MCF‐7 cells, growth‐arrested by serum starvation, were stimulated with recombinant human insulinlike growth factor‐1 (IGF‐I). An increase in DNA synthesis was induced 20 hr later, which was as effective as that induced by serum. The increase in DNA synthesis was sign