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Role of AKT1 in 17β-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells

✍ Scribed by Shakeel Ahmad; Nadia Singh; Robert I. Glazer


Book ID
113994464
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
363 KB
Volume
58
Category
Article
ISSN
0006-2952

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## Abstract The insulin‐like growth factors (IGFs) are potent mitogens for breast cancer cells and their activity is modulated by high affinity binding proteins (IGFBPs). We have recently shown that IGFBP‐1 purified from human amniotic fluid neutralizes IGF‐I‐dependent growth of MCF‐7 cells. In thi