Synergistic interaction between cisplatin and tamoxifen delays the emergence of cisplatin resistance in head and neck cancer cell lines
✍ Scribed by Bunzo Nakata, Kathleen D. Albright…
- Book ID
- 120776412
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 821 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## Background Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the clinical outcome and evaluate intrinsic cisplatin sensitivity are, therefore, required. ## Methods Cisplatin sensitivity, lysosom
## Abstract ## Background Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance. ##