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Hyperphosphorylation of replication protein A in cisplatin-resistant and -sensitive head and neck squamous cell carcinoma cell lines

✍ Scribed by Karoline C. Manthey; Jason G. Glanzer; Diana D. Dimitrova; Greg G. Oakley

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 419 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21234

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Resistance to chemotherapy is a major limitation in the treatment of head and neck squamous cell carcinomas (HNSCCs), accounting for high mortality rates in patients. Here, we investigated the role of replication protein A (RPA) in cisplatin and etoposide resistance.

Methods

We used 6 parental HNSCC cell lines. We also generated 1 cisplatin‐resistant progeny subline from a parental cisplatin‐sensitive cell line, to examine cisplatin resistance and sensitivity with respect to RPA2 hyperphosphorylation and cell‐cycle response.

Results

Cisplatin‐resistant HNSCC cell levels of hyperphosphorylated RPA2 in response to cisplatin were 80% to 90% greater compared with cisplatin‐sensitive cell lines. RPA2 hyperphosphorylation could be induced in the cisplatin‐resistant HNSCC subline. The absence of RPA2 hyperphosphorylation correlated with a defect in cell‐cycle progression and cell survival.

Conclusion

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