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Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck

✍ Scribed by B.M. Lippert; A. Teymoortash; C. Külkens; B.J. Folz; J.A. Werner

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
231 KB
Volume
34
Category
Article
ISSN
0196-8092

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✦ Synopsis

Abstract

Background and Objective

In the last years, photodynamic therapy, performed with hematoporphyrin derivatives, gained in importance for the treatment of superficially situated malignomas. The use of hematoporphyrin as photosensitizer is limited especially by the low depth of penetration and its side effects. The aim of the present study was to evaluate the effectiveness of photodynamic therapy with anthracyclin derivates in squamous cell carcinoma cell lines.

Study Design/Materials and Methods

The photodynamic effects of the anthracyclin derivates adriamycin and epirubicin as well as the effects of the hematoporphyrin derivatives photofrin‐II and photosan‐3 were examined and compared in 10 squamous cell carcinoma cell lines derived from head and neck tumors.

Results

Beside their cytostatic effect, the applied cytostatics revealed a marked photodynamic effect. A statistically significant difference for photodynamic effects of both cytostatic agents and the hematoporphyrin derivates could not be shown.

Conclusions

These results revealed that the above mentioned cytostatics could be considered as possible alternative photosensitizer for photodynamic therapy. Lasers Surg. Med. 34:391–397, 2004. © 2004 Wiley‐Liss, Inc.

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