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Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine

✍ Scribed by Massimo Donadelli; Chiara Costanzo; Stefania Beghelli; Maria Teresa Scupoli; Mario Dandrea; Antonio Bonora; Paolo Piacentini; Alfredo Budillon; Michele Caraglia; Aldo Scarpa; Marta Palmieri

Book ID
113486077
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
961 KB
Volume
1773
Category
Article
ISSN
0167-4889

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Trichostatin A, an inhibitor of histone
Trichostatin A, an inhibitor of histone deacetylases, strongly suppresses growth of pancreatic adenocarcinoma cells
✍ Massimo Donadelli; Chiara Costanzo; Laura Faggioli; Maria Teresa Scupoli; Patric πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 227 KB

## Abstract In cells with an altered __p53__ gene, the expression of p21^__WAF1__/__CIP1__^, a potent inhibitor of cyclin‐dependent kinases, can be induced by histone deacetylase (HDAC) inhibitors via a __p53__‐independent pathway, which may play a critical role in arrest of cell growth. Accordingl