𝔖 Bobbio Scriptorium
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Synergistic inhibition of HIV-1 by an antisense oligonucleotide and nucleoside analog reverse transcriptase inhibitors

✍ Scribed by Gareth J Veal; Sudhir Agrawal; Randal A Byrn


Book ID
114145142
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
319 KB
Volume
38
Category
Article
ISSN
0166-3542

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## Abstract An β€˜active analog’ approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV‐1 reverse transcriptase. The preliminary results indicate that the O2, O4β€², and O5β€² atoms are capable of adopting a unique pharmacophoric patte