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Synergistic induction of monooxygenase activity by glucocorticoids and polycyclic aromatic hydrocarbons in human fetal hepatocytes in primary monolayer culture

✍ Scribed by J.Michael Mathis; Russell A. Prough; Evan R. Simpson

Book ID
115707184
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
1009 KB
Volume
244
Category
Article
ISSN
0003-9861

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## Abstract To determine whether human liver responds to treatment with aromatic hydrocarbons (AHs) with induction of the multidrug resistance (mdr) gene product P‐glycoprotein and whether AH induction of __mdr__ involves the Ah receptor, we compared induction of __mdr__ mRNA with induction of cyto