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Synergistic effects of peroxynitrite on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts

โœ Scribed by Yu-Chao Chang; Kuo-Wei Tai; Ming-Yung Chou; Tsui-Hwa Tseng


Book ID
119536914
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
173 KB
Volume
118
Category
Article
ISSN
0378-4274

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โœ K. K. Wary; R. N. Sharan ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 488 KB ๐Ÿ‘ 1 views

Arecoline, an active alkaloid of Areca catechu L., and sodium nitrite, a food additive, are highly cytotoxic and cytostatic on the Hep 2 cell line when administered in an acidic environment (pH 4.2) in the presence of S-9 mixture. Hep 2 cells (10(6)) were treated with either 0.145, 0.725 or 1.449 mM