Synergistic effects of hypoxia and BMP-2 on the human articular chondrocyte phenotype
β Scribed by Lafont, J.E.; Poujade, F.-A.; Pasdeloup, M.; Aubert-Foucher, E.; Damour, O.; Neyret, P.; Mallein-Gerin, F.
- Book ID
- 122295468
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 128 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1063-4584
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## Abstract ## Objective To uncover the mechanism by which hypoxia enhances cartilage matrix synthesis by human articular chondrocytes. ## Methods The hypoxic response was investigated by exposing normal (nonarthritic) human articular chondrocyte cultures to 20% oxygen and 1% oxygen. Induction o
## Abstract In this study, we investigated if monolayer expansion of adult human articular chondrocytes (AHAC) on specific substrates regulates cell phenotype and postβexpansion multilineage differentiation ability. AHAC isolated from cartilage biopsies of five donors were expanded on plastic dishe