## Abstract Skin cells for transplantation are routinely prepared by growing patient keratinocytes in a semi‐defined cocktail of growth factors, including serum and feeder cells. However, these reagents require substantial risk remediation and can contribute to transplant rejection. Microcarrier cu
P203 Phenotypic characterization and redifferentiation of human articular chondrocytes expanded on microcarriers
✍ Scribed by K. Schrobback; T. Klein; M. Schütz; D. Hutmacher; D. Leavesley; Z. Upton; J. Malda
- Book ID
- 114350074
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 72 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1063-4584
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## Abstract Chondrocytes, the only cell type present in articular cartilage, regulate tissue homeostasis by a fine balance of metabolism that includes both anabolic and catabolic activities. Therefore, the biology of chondrocytes is critical for understanding cartilage metabolism. One major limitat
## Abstract In this study, we investigated if monolayer expansion of adult human articular chondrocytes (AHAC) on specific substrates regulates cell phenotype and post‐expansion multilineage differentiation ability. AHAC isolated from cartilage biopsies of five donors were expanded on plastic dishe