Synergistic effects of acetylcholine and glutamate on the release of arachidonic acid from striatal neurons in culture
✍ Scribed by M. Tencé; N. Murphy; J. Cordier; J. Prémont; J. Glowinski
- Book ID
- 113401633
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 80 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0928-4257
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The role of endogenously released arachidonic acid in the control of the NMDA (50 microM)-evoked release of [3H]-acetylcholine previously formed from [3H]-choline was investigated in striosome-enriched areas and in the matrix of the rat striatum using a microsuperfusion procedure in vitro. Experimen
The lipid mediators generated by phospholipases A(2) (PLA(2)), free arachidonic acid (AA), eicosanoids, and platelet-activating factor, modulate neuronal activity; when overproduced, some of them become potent neurotoxins. We have shown, using primary cortical neuron cultures, that glutamate and sec