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Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neurons

✍ Scribed by R.J Williams; M Maus; N Stella; J Glowinski; J Prémont


Book ID
116129433
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
236 KB
Volume
74
Category
Article
ISSN
0306-4522

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The lipid mediators generated by phospholipases A(2) (PLA(2)), free arachidonic acid (AA), eicosanoids, and platelet-activating factor, modulate neuronal activity; when overproduced, some of them become potent neurotoxins. We have shown, using primary cortical neuron cultures, that glutamate and sec