✦ LIBER ✦

Synergistic effect of two HLA heterodimers in the susceptibility to celiac disease in Tunisia

✍ Scribed by F. Bouguerra; M.C. Babron; J.F. Eliaou; A. Debbabi; J. Clot; F. Khaldi; L. Greco; F. Clerget-Darpoux

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 84 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:4<413::aid-gepi6>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

The DR and DQ HLA genotypes of 94 Tunisian children affected with celiac disease are analyzed so that we can gain a better understanding of the HLA component of this disease. All of them carry at least one of two specific heterodimers: a DQ heterodimer, encoded by DQA1*0501, DQB1*0201 and/or a DR heterodimer, encoded by the nonpolymorphic gene DRA and the DRB4 gene. Quantifying the relative penetrances of all susceptible genotypes gives evidence for a synergistic effect of these two heterodimers and for a dose effect of the alleles encoding the b chains of these two heterodimers. The DR3DR7 individuals have the greatest risk. They present the two kinds of heterodimers and carry two DQB1*0201 alleles. Celiac disease is the first HLA-associated disease for which the at-risk genotypes are so well delineated. Genet. Epidemiol. 14:413-422, 1997.

📜 SIMILAR VOLUMES

Susceptibility to hard metal lung diseas

Susceptibility to hard metal lung disease is strongly associated with the presence of glutamate 69 in HLA-DPβ chain

✍ Ilaria Potolicchio; Giovanni Mosconi; Alessandra Forni; Benoit Nemery; Paolo Seg 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 328 KB

HLA Class ii sequence polymorphisms and

HLA Class ii sequence polymorphisms and susceptibility to rheumatoid arthritis in greeks. the hla–drβ shared-epitope hypothesis accounts for the disease in only a minority of greek patients

✍ Kyriaki A. Boki; Gabriel S. Panayi; Robert W. Vaughan; Alexandros A. Drosos; Har 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 633 KB

Objective. In Northern Europeans, rheumatoid arthritis (RA) is strongly associated with a relatively conserved pentapeptide sequence of HLA-DRP found notably in the HLA-DR4 subtypes Dw4 and Dw14 and in DRl. A previous serologic study of HLA class I1 polymorphism in a Greek population with RA failed