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Synergistic Effect of Arsenic Trioxide and Flt3 Inhibition on Cells with Flt3 Internal Tandem Duplication

✍ Scribed by Shinichiro Takahashi; Hideo Harigae; Hisayuki Yokoyama; Izumi Ishikawa; Shouri Abe; Masue Imaizumi; Takeshi Sasaki; Mitsuo Kaku


Book ID
111835591
Publisher
Carden Jennings Publishing
Year
2006
Tongue
English
Weight
296 KB
Volume
84
Category
Article
ISSN
0925-5710

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte