Synergistic effect between apolipoprotein E and apolipoprotein A1 gene polymorphisms in the risk for coronary artery disease
โ Scribed by Taranjit Singh Rai; Madhu Khullar; B. S. Sehrawat; Monica Ahuja; Praveen Kumar Sharma; Rajesh Vijayvergiya; Anil Grover
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 226 KB
- Volume
- 313
- Category
- Article
- ISSN
- 0300-8177
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A common polymorphism in the ฮฑ1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t
## Abstract The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE\*2, APOE\*3, and APOE\*4 alleles influences plasma levels of apolipoprotein E and cholesterol. Besides its role in lipid transport, the APOE\*4 allele is a genetic risk fact