Synergistic antinociceptive interaction between aspirin and tramadol, the atypical opioid analgesic, in the rat
✍ Scribed by L. A. Salazar; R. Ventura Martínez; F. J. López-Muñoz
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 607 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0272-4391
No coin nor oath required. For personal study only.
✦ Synopsis
In order to assess a possible synergistic antinociceptive interactions, the analgesic effects of aspirin per US (acetyl salicylic acid or "ASA"), a nonsteroidal anti-inflammatory drug (NSAID), and tramadol S.C. (TRA), an atypical opioid analgesic, administered either separately or in combination were determined in a model of pain-induced functional impairment in the rat, groups of six rats received either vehicle,
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There is evidence that B vitamins produce antinociception in animals. However, potentiation of NSAID-induced antinociception by B vitamins is unclear. The current study was designed to investigate the antinociceptive interaction between a mixture of B vitamins and either acetaminophen or metamizol.
## Abstract Diclofenac and tramadol are drugs widely used for the treatment of pain. However, side effects may limit their use. As both drugs produce side effects that are dose‐dependent, it seems appropriate to combine them in order to reduce the requirements for efficacy and, consequently, side e