Evaluation of the interaction between tramadol and diclofenac in several models of nociception in the rat

✍ Scribed by Juan Rodríguez-Silverio; Myrna Déciga-Campos; Gerardo Reyes-García; Miriam del Carmen Carrasco-Portugal; Francisco J. Flores-Murrieta

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 93 KB
• Volume: 72
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.20440

✦ Synopsis

Abstract

Diclofenac and tramadol are drugs widely used for the treatment of pain. However, side effects may limit their use. As both drugs produce side effects that are dose‐dependent, it seems appropriate to combine them in order to reduce the requirements for efficacy and, consequently, side effects. The purpose of this study was to evaluate the possible synergistic effect of these drugs in three experimental models of nociception in the rat. Dose‐response curves for diclofenac and tramadol were constructed in three models, thermal hyperalgesia, formalin, and hot plate. From these curves, ED~40~ or ED~30~ (according to the model employed) values were obtained and isobolographic analyses were carried out based on 0.5:0.5 proportions. Synergistic interactions were observed in the thermal hyperalgesia and hot plate models and an additive interaction was obtained in the formalin test. These results suggest a good therapeutic potential of this combination in the treatment of pain. Drug Dev Res 72: 391–396, 2011. © 2011 Wiley‐Liss, Inc.