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Synergistic antileukemic action of a combination of inhibitors of DNA methylation and histone methylation

✍ Scribed by Richard L. Momparler; Youssef Idaghdour; Victor E. Marquez; Louise F. Momparler

Book ID
113773699
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
781 KB
Volume
36
Category
Article
ISSN
0145-2126

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## Abstract During tumorigenesis, cancer‐related genes can be silenced by aberrant DNA methylation and by changes in chromatin structure. It has been reported that 5‐aza‐2′‐deoxycytidine, a potent inhibitor of DNA methylation, in combination with histone deacetylase inhibitors, can produce a synerg