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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

โœ Scribed by Zhao, Quan; Rank, Gerhard; Tan, Yuen T; Li, Haitao; Moritz, Robert L; Simpson, Richard J; Cerruti, Loretta; Curtis, David J; Patel, Dinshaw J; Allis, C David

Book ID
109965649
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
598 KB
Volume
16
Category
Article
ISSN
1545-9993

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Methylation of histone H3 and H4 by PRMT
Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription
โœ Sarmila Majumder; Lapo Alinari; Satavisha Roy; Tyler Miller; Jharna Datta; Said ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 386 KB

## Abstract In an effort to understand the epigenetic regulation of ribosomal RNA gene (rDNA) expression we have previously demonstrated the role of DNA methyltransferases and methyl CpG binding proteins in rRNA synthesis. Here, we studied the role of protein arginine methyltransferase PRMT5 and th