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Synergism of minocycline and amitriptyline in cutaneous hyperpigmentation

✍ Scribed by Basler, Rodney S.W.; Goetz, C. Stephen


Book ID
122711511
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
111 KB
Volume
12
Category
Article
ISSN
1097-6787

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## Abstract Alkaptonuria, a rare autosomal‐recessive disorder caused by mutations in the __HGD__ gene and a deficiency of homogentisate 1,2‐dioxygenase, is characterized by accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue resulting in joint disease. Certain