Aphidicolin, a specific inhibitor of DNA polymerase alpha, is known to induce chromosomal aberrations. At concentrations that did not greatly affect mitotic index, aphidicolin induced a striking number of chromosome gaps and breaks distributed in a highly nonrandom manner in cultured human lymphocyt
โฆ LIBER โฆ
Synergism between aphidicolin and adenoviruses in the induction of breaks at fragile sites on human chromosomes
โ Scribed by D. Caporossi; S. Bacchetti; B. Nicoletti
- Book ID
- 119104812
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 815 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0165-4608
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It has been suggested that fragile sites on human chromosomes predispose to specific rearrangements seen in cancer. Renal cell carcinoma is characterised by recurrent aberrations of chromosome 3p and frequent rearrangements of chromosome 5q. To investigate whether there might be an association betwe