Syndrome of inappropriate antidiuretic hormone secretion in papillary serous surface carcinoma of the peritoneum

✍ Scribed by Resnik, Edward; Bender, David

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 226 KB
• Volume: 61
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/(sici)1096-9098(199601)61:1<63::aid-jso14>3.0.co;2-y

✦ Synopsis

A case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in a patient with suboptimally cytoreduced stage I11 papillary serous surface carcinoma of the peritoneum is described. After the primary surgery, the patient refused further therapy. Within a month bilateral pleural effusions and abdominal ascites compelled the patient to accept treatment with carboplatin and cyclophosphamide. Ten days following the chemotherapy, she was admitted in a disoriented state with serum sodium of 1 17-mEq/L. During the evaluation, treatment, and subsequent followup, the diagnosis of SIADH was confirmed. Numerous disease processes have been associated with the development of SIADH; however, there have been few reports in gynecologic malignancies. Possible etiology and clinical management of this patient are briefly discussed.