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Ectopic atrial natriuretic peptide production in small cell lung cancer with the syndrome of inappropriate antidiuretic hormone secretion

โœ Scribed by K. Shimizu; S. Nakano; Y. Nakano; M. Ando; K. Seki; N. Kameda


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
448 KB
Volume
68
Category
Article
ISSN
0008-543X

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From 1976 to 1980,18 of the 250 patients (7%) seen with small cell carcinoma of the lung had clinically evident inappropriate secretion of antidiuretic hormone (ADH). Hyponatremia was usually severe (1 16 f 7 meq/l), and eight patients showed symptoms of water intoxication at the time of diagnosis.

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## Background: Tumors and tumor cell lines from two patients with small cell lung carcinoma (sclc) (one with and one without hyponatremia) were studied. ectopic production and prohormone processing of atrial natriuretic peptide (anp) were investigated to determine if a biologically active peptide w