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Syndecans: proteoglycan regulators of cell-surface microdomains?

✍ Scribed by Couchman, John R.


Book ID
109958020
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
289 KB
Volume
4
Category
Article
ISSN
1471-0072

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Binding of fibroblast growth factors (FGFs) to receptor tyrosine kinases (FGFRs) and signaling is facilitated by binding of FGF to heparan sulfate proteoglycans (HSPGs). There are multiple families of HSPGs, including extracellular and cell surface forms. An important and potentially controversial q