Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the
โฆ LIBER โฆ
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis
โ Scribed by Echtermeyer, Frank; Bertrand, Jessica; Dreier, Rita; Meinecke, Ingmar; Neugebauer, Katja; Fuerst, Martin; Lee, Yun Jong; Song, Yeong Wook; Herzog, Christine; Theilmeier, Gregor
- Book ID
- 109926217
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 768 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1078-8956
- DOI
- 10.1038/nm.1998
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
ADAMTS-4 and ADAMTS-5: Key enzymes in os
โ
Priyanka Verma; Dr. Krishna Dalal
๐
Article
๐
2011
๐
John Wiley and Sons
๐
English
โ 185 KB
479 THE REGULATION OF THE ADAMTS4 AND AD
โ
J. Bondeson; S.D. Wainwright; C. Hughes; B. Caterson
๐
Article
๐
2010
๐
Elsevier Science
๐
English
โ 228 KB
NF-kB : a potential mediator of adamts-5
โ
T. Ruike; G.E. Striker; F. Zheng; D.J. Leong; F. Grosjean; R.J. Majeska; J.C. Ia
๐
Article
๐
2012
๐
Elsevier Science
๐
English
โ 181 KB
Deletion of active ADAMTS5 prevents cart
โ
Glasson, Sonya S.; Askew, Roger; Sheppard, Barbara; Carito, Brenda; Blanchet, Tr
๐
Article
๐
2005
๐
Nature Publishing Group
๐
English
โ 393 KB
Aggrecan degradation in human articular
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
โ
Ruo-Hua Song; Micky D. Tortorella; Anne-Marie Malfait; James T. Alston; Zhiyong
๐
Article
๐
2007
๐
John Wiley and Sons
๐
English
โ 403 KB
๐ 2 views
## Abstract ## Objective Recent published studies have shown that cartilage from ADAMTSโ5โknockout mice, but not ADAMTSโ4โ or ADAMTSโ1โknockout mice, is significantly protected from degradation. The present study was undertaken to evaluate the respective roles of these enzymes in human cartilage b
Evidence of a novel aggrecan-degrading a
โ
Fraser M. Rogerson; Heather Stanton; Charlotte J. East; Suzanne B. Golub; Leonie
๐
Article
๐
2008
๐
John Wiley and Sons
๐
English
โ 263 KB
๐ 2 views