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Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

โœ Scribed by Echtermeyer, Frank; Bertrand, Jessica; Dreier, Rita; Meinecke, Ingmar; Neugebauer, Katja; Fuerst, Martin; Lee, Yun Jong; Song, Yeong Wook; Herzog, Christine; Theilmeier, Gregor


Book ID
109926217
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
768 KB
Volume
15
Category
Article
ISSN
1078-8956

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## Abstract ## Objective Recent published studies have shown that cartilage from ADAMTSโ€5โ€“knockout mice, but not ADAMTSโ€4โ€“ or ADAMTSโ€1โ€“knockout mice, is significantly protected from degradation. The present study was undertaken to evaluate the respective roles of these enzymes in human cartilage b