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ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

✍ Scribed by Priyanka Verma; Dr. Krishna Dalal

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
185 KB
Volume
112
Category
Article
ISSN
0730-2312

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✦ Synopsis

Osteoarthritis (OA) is a progressive disease of the joints characterized by degradation of articular cartilage. Although disease initiation may be multi-factorial, the cartilage destruction appears to be a result of uncontrolled proteolytic extracellular matrix destruction. A major component of the cartilage extracellular matrix is aggrecan, a proteoglycan that imparts compressive resistance to the tissue. Aggrecanase-mediated aggrecan degradation is a significant event in early stage OA. The relative contribution of individual ADAMTS-4 and ADAMTS-5 proteinases to cartilage destruction during OA has not been resolved completely. This review reveals that both ADAMTS-4/ADAMTS-5 are responsible for aggrecan degradation in a human model of OA, and is expected to list down the rational strategies which are being focussed for therapeutic intervention in OA.

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