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Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype

✍ Scribed by Tiago De Oliveira, Ivane Abiatari, Susanne Raulefs, Danguole Sauliunaite, Mert Erkan, Bo Kong, Helmut Friess, Christoph W Michalski, Jörg Kleeff


Book ID
119901823
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
753 KB
Volume
11
Category
Article
ISSN
1476-4598

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## Abstract Activating mutation of __K‐ras__ and inactivation of __DPC4__ are two common genetic alterations that occur in the development and progression of pancreatic ductal adenocarcinomas (PDAC). A separate common event in PDAC progression is increased expression of phosphotyrosine kinase recep