Synaptotagmin II negatively regulates MHC class II presentation by mast cells
โ Scribed by Dana Baram; Ze Peng; Ora Medalia; Yoseph A Mekori; Ronit Sagi-Eisenberg
- Book ID
- 117325477
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 155 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0161-5890
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## Abstract We first classified 12 malignant glioma cell lines into three different groups (types 1โ3) with respect to major histocompatibility complex (MHC) class II expression and analyzed each group based on the different expression status of the class II transactivator (CIITA) gene. Glioma type
The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their