Synaptopodin and the spine apparatus organelle—Regulators of different forms of synaptic plasticity?
✍ Scribed by Andreas Vlachos
- Book ID
- 116176658
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- German
- Weight
- 400 KB
- Volume
- 194
- Category
- Article
- ISSN
- 0940-9602
No coin nor oath required. For personal study only.
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## Abstract The function of the spine apparatus in dendritic spines and the cisternal organelles in axon initial segments is little understood. The actin‐associated protein, synaptopodin, is essential for the formation of these organelles which are absent in synaptopodin −/− mice. Here, we used syn
Long-term potentiation (LTP) and long-term depression (LTD) are calcium-dependent forms of synaptic plasticity observed in area CA1 of the hippocampus. Low-frequency tetani (1-5 Hz) activates protein phosphatases to induce LTD, whereas high-frequency tetani (>25 Hz) activates protein kinases to indu