syn -Selective Kobayashi Aldol Reaction Using Acetals
โ Scribed by Tsukada, Hiroyuki; Mukaeda, Yuki; Hosokawa, Seijiro
- Book ID
- 120005532
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 379 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The aldol reaction of aldehydes with bromofluoroketene ethyl trimethylsilyl acetal in the presence of a catalytic amount of a ehiral Lewis acid at -780C provides a mixture of the corresponding synand anti-o~-bromo-o~-fluoro-~-hydroxy esters with high enantioselectivities (up to 99% ee). Reaction te
The low temperature transmetallation of the lithium dienolate of 2-cyclohexene-l-one or P-cyclopentene-1 -one with chlorotitanium triisopropoxide or bis(n5-cyclopentadienyl)dichlorozirconium gives the Z,E-titanium or zirconium dienolate. These transition metal dienolates participate in aldol reactio
A practical and convenient organocatalytic strategy is developed to provide a direct route to syn-selective aldol products in the presence of water. The siloxy serine organocatalyst mediates the direct aldol reaction of TBSO-protected hydroxyacetone with a variety of aldehydes to provide the aldol p