## Abstract Pilot study of nabilone in Huntington's disease (HD). Doubleβblind, placeboβcontrolled, crossβover study of nabilone versus placebo. Primary outcome, Unified Huntington's Disease Rating Scale (UHDRS) total motor score. Secondary measures: UHDRS subsections for chorea, cognition and beha
Symptomatic Treatment of Huntington Disease
β Scribed by Octavian R. Adam; Joseph Jankovic
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 230 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1933-7213
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## Abstract The purpose of this study was to quantify gait impairments in presymptomatic and symptomatic Huntington's disease (HD) subjects, and examine sensitivity of gait measures. Our sample (n = 65) included presymptomatic mutation carriers (PMC) (n = 15), symptomatic HD subjects (SHD) (n = 30)
Previous research by our group demonstrated a longitudinal change in caudate volume for symptomatic subjects with Huntington's disease (HD), and suggested that volume of the caudate may be a useful outcome measure for therapeutic studies in symptomatic patients. The current study was designed to det