Expansion of a 27 CAG repeat allele into a symptomatic Huntington disease-producing allele
β Scribed by Kelly, Thaddeus E.; Allinson, Patricia; McGlennen, Ronald C.; Baker, Janice; Bao, Yongde
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 7 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19991105)87:1<91::aid-ajmg21>3.0.co;2-j
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The fragile sites FRAXA and FRAXE, located βΌ600 kb apart on Xq27.3 and Xq28, respectively, are due to a CGG trinucleotide repeat expansion. Although the expansion mechanism for these and other trinucleotide repeat disorders remains unknown, the similarities between the FRAXA and FRAXE regions sugges
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