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Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca h ydnoides

✍ Scribed by Harrigan, George G.; Luesch, Hendrik; Yoshida, Wesley Y.; Moore, Richard E.; Nagle, Dale G.; Paul, Valerie J.; Mooberry, Susan L.; Corbett, Thomas H.; Valeriote, Fred A.

Book ID: 126131433
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 55 KB
Volume: 61
Category: Article
ISSN: 0163-3864
DOI: 10.1021/np980321c

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## Abstract Symplostatin 1, an analog of dolastatin 10, was recently isolated from cyanobacteria of the genus __Symploca__. Symplostatin 1 is a potent inhibitor of cell proliferation with IC~50~ values in the low nanomolar range and it exhibits efficacy against a variety of cancer cell types. Sympl

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