Symmetry and chiral recognition; separation of enantiomers on triacetyl-cellulose columns

✍ Scribed by Roland Isaksson; H»kan Wennerström; Olof Wennerström

• Book ID: 104204167
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 701 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86733-8

✦ Synopsis

The role of molecular symmetry in chiral recognition is investigated by use of statistlcal methods; a theoretical expression for the difference in behaviour between q-symmetric and s--symmetric (n>l) chiral molecules on a chirsl column being derived. The results are compared with experimental data obtained from resolutlons by column chromatography on triacetylcellulose. It is shown both theoretically and experimentally that the Csymmett-tc molecules stand a better chance to be successfully resolved than _C1-symmetric species. I -1 2 3 4 5a *In case of partial raoqlutions the a-values have been evaluated from the polarimeter curve rather than from the UV-abflption curve. This might have led to slightly too l&e a-values and an uncertainty in the assignment to the intervals a = 1.0-l .19 and a = 1.20-1.39.