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Swelling behavior and biocompatibility of Carbopol-containing superporous hydrogel composites

✍ Scribed by Cui Tang; Lichen Yin; Jing Yu; Chunhua Yin; Yuanying Pei

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
340 KB
Volume
104
Category
Article
ISSN
0021-8995

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✦ Synopsis

Abstract

Carbopol‐containing superporous hydrogel composites (SPHCc) with fast swelling and high swelling ratio were prepared using free radical copolymerization. Swelling behavior of the SPHCc was studied in various salt and pH solutions and their biocompatibility was evaluated using tissue damage and cytotoxicity studies. The swelling ratio of the SPHCc decreased with the increase of Carbopol/monomer ratio and was sensitive to pH and ionic strength of the swelling medium. The release of insulin from the SPHCc was rapid in 0.01__M__ phosphate buffered saline (PBS, pH 7.4). In the jejunum mucosal membrane toxicity studies in rat, no significant morphological damage was observed after application of SPHCc. Besides, no damage of the Caco‐2 monolayers was detected after incubation with SPHCc in the trypan blue and propidium iodide tests. On the basis of these results, it was concluded that the SPHCc might be a safe and effective carrier for peroral delivery of peptide and protein drugs. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007

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