𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Swelling and Viscoelastic Characterisation of pH-Responsive Chitosan Hydrogels for Targeted Drug Delivery

✍ Scribed by Susannah L. Jahren; Michael F. Butler; Sarah Adams; Ruth E. Cameron

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
340 KB
Volume
211
Category
Article
ISSN
1022-1352

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Chitosan hydrogels have been investigated as potential vehicles for targeted drug delivery. The gels were permanently crosslinked with conventional crosslinking agent, glutaraldehyde and the naturally occurring non‐toxic crosslinking agent genipin in both the monomer and polymerised states. The swelling behaviour of all the gels was highly pH dependent. The gels with the lowest crosslink density not only had an increased rate of diffusion but also an increased total release. It is shown that by altering the type and degree of crosslinking in a chitosan hydrogel it is possible to change the swelling and elastic characteristics of the material, which could be of potential interest as an environment responsive drug delivery matrix.

magnified image

πŸ“œ SIMILAR VOLUMES

Swelling characteristics and drug delive
Swelling characteristics and drug delivery properties of nifedipine-loaded pH sensitive alginate–chitosan hydrogel beads
✍ Ya-Ni Dai; Ping Li; Jun-Ping Zhang; Ai-Qin Wang; Qin Wei πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 243 KB πŸ‘ 1 views

## Abstract The aim of the present work was to investigate the swelling behavior and __in vitro__ release of nifedipine from alginate–chitosan hydrogel beads. Structure and surface morphology of the hydrogel were characterized by FTIR and SEM, respectively. Alginate–chitosan mixed beads and alginat

Effect of Chemical Crosslinking on the S
Effect of Chemical Crosslinking on the Swelling and Shrinking Properties of Thermal and pH-Responsive Chitosan Hydrogels
✍ Francisco M. Goycoolea; Angeles Heras; Inmaculada Aranaz; Gemma Galed; MarΓ­a E. πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 230 KB

## Abstract The ability to form a gel through the physical or chemical crosslinking of chitosan has been well documented. In an attempt to mimic biological systems, thermal and pH‐sensitive chitosan cylindrical hydrogels were produced by a combination of physical and chemical crosslinking processes