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SV40 Large T Antigen Hexamer Structure: Domain Organization and DNA-Induced Conformational Changes

✍ Scribed by Margaret S. VanLoock; Alexander Alexandrov; Xiong Yu; Nicholas R. Cozzarelli; Edward H. Egelman


Book ID
114319030
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
222 KB
Volume
12
Category
Article
ISSN
0960-9822

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With the aim of forming the β€˜lock-washer’ conformation of the origin-binding domain of SV40 large T antigen in solution, using structure-based analysis an intermolecular disulfide bridge was engineered into the origin-binding domain to generate higher order oligomers in solution. The 1.7β€…Γ… resolutio