Structure-based design of a disulfide-li
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Meinke, Gretchen ;Phelan, Paul ;Fradet-Turcotte, AmΓ©lie ;Archambault, Jacques ;B
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Article
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2011
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International Union of Crystallography
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English
β 789 KB
With the aim of forming the βlock-washerβ conformation of the origin-binding domain of SV40 large T antigen in solution, using structure-based analysis an intermolecular disulfide bridge was engineered into the origin-binding domain to generate higher order oligomers in solution. The 1.7β Γ resolutio