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Sustained relief of dystonia following cessation of deep brain stimulation

✍ Scribed by Matthew O. Hebb; Paula Chiasson; Anthony E. Lang; Robert M. Brownstone; Ivar Mendez

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 110 KB
Volume: 22
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.21616

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✦ Synopsis

Abstract

We describe the unusual clinical course of a patient with cranial dystonia (i.e., Meige syndrome) and additional upper limb involvement, who developed sustained relief of motor symptoms following cessation of a prolonged course of bilateral pallidal deep brain stimulation (DBS). Early response to therapy proved titratable and reversible; however, the patient gained independence from DBS in the fifth postoperative year and has since been more than a year without treatment or exacerbation of motor symptoms. Among the potential explanations for these neurological benefits lies the intriguing possibility that DBS therapy may have the capacity to induce plastic change that lessens or obviates the need for further treatment in susceptible patients. © 2007 Movement Disorder Society

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