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Sustained, clonal karyotype abnormalities in the Philadelphia chromosome negative cells of CML patients successfully treated with Imatinib

✍ Scribed by Meeus, P; Demuynck, H; Martiat, Ph; Michaux, L; Wouters, E; Hagemeijer, A

Book ID: 110055346
Publisher: Nature Publishing Group
Year: 2003
Tongue: English
Weight: 91 KB
Volume: 17
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2402791

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## Abstract ## BACKGROUND. Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)‐negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate. In some patients, CCA/Ph‐negative status was associated with