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Susceptibility to p53 dependent apoptosis correlates with increased levels of Gas2 and Gas3 proteins

✍ Scribed by Brancolini, Claudio; Marzinotto, Stefania; Schneider, Claudio


Book ID
110015652
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
474 KB
Volume
4
Category
Article
ISSN
1350-9047

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of