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Susceptibility gene(s) for Alzheimer's disease on chromosome 10

✍ Scribed by Corinne Lendon; Nick Craddock

Book ID
117343476
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
38 KB
Volume
24
Category
Article
ISSN
0166-2236

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Linkage data from 92 FAD kindreds were analyzed by lod score analysis under various assumptions of disease penetrance, marker allele frequencies, and heterogeneity. Multilocus linkage analysis supports the existence of a gene in 40%-65% of families with predominantly late-onset illness (after age 65