Survival Stratification Pattern of Colorectal Carcinoma with CEA MMP-2 and p27kip1 Expression
β Scribed by Jin Gu
- Book ID
- 119242991
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 58 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1097-6779
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## Background: The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (crc). beta-catenin up-regulates c-myc and cyclin d1, which antagonize the association of the cyclin-dependent kinase (cdk) inhibitor, p27(kip1), with cdk2,
## BACKGROUND. Previous studies have shown that low levels of p27 Kip1 , an inhibitor of G1 cyclin-dependent kinases, are associated with high aggressiveness and poor prognosis in a variety of cancers. Decreased levels of p27 are caused, at least in part, by acceleration of the rate of its ubiquit