Survival of pleomorphic sarcoma-37 transplanted virgin female DBA/2J mice: Hyperthermia and hyperglycemia, alone and in combination with drugs

✍ Scribed by Ronald E. Orth; Howard J. Swidler; Milo S. Zarakov

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 260 KB
• Volume: 66
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600660335

✦ Synopsis

Sarcoma-37 (S-37) transplanted DBA/2J mice were submitted to a controlled whole body hyperglycemic-hyperthermic ("double attack") treatment. A single exposure to the 3-hr 400-500-mg% blood glucose level coupled with 1 hr of whole body 40.0 degrees warming was safe and extended longevity by 40% over the nontreated controls. This increase suggests that additive or potentiated effects follow the two-parameter procedure. The treatment safety and resultant increased longevity were not enhanced by single-dose chemotherapy with doxorubicin and/or dacarbazine.